don't use anyone else, no need because your products are fab. Love amphora, have been using your products for almost 12 years now. I love Amphora Aromatics, Frankincense and Rose Face cream is my favourite but there are loads of products I wouldn't be without now. Our comfrey has been tested on willing participants, never animals, and is safe to use on your skin to combat. PAs could be excluded in the non-spiked cream with a limit of detection of 8 g/kg. Great company to deal with all very friendly and helpful and service is first class and quick delivery and of course products BRILLIANT. Comfrey (Symphytum officinale) is sometimes used on the skin to treat wounds and reduce inflammation from sprains and broken bones. Vogel Comfrey Cream is safe to use externally. In this study, lycopsamine served as a model substance for measuring the extent of skin permeation of PAs following the application of a spiked comfrey cream (Symphytum officinale s.l.) to abdominal skin from human donors in Franz diffusion cells. More importantly my clients love them too. Comfrey/plantain Ointment soothes and moisturises dry, cracked skin and. I love these oils been using them daily for several years. It has been effectively used for nappy rash and is absolutely safe on babies skin. We always recommend them to friends and family and work colleagues. They are excellent quality, nothing is too much for the staff in helping you and they're all friendly. I'm happy to see Amphora going from strength to strength and wish them all good wishes for the future. I started with other companies but chose Amphora because of the reliability and quality of the products. I have been buying from Amphora for nearly 24 years. Gorgeous aromas and quality creams / oils, keeps me going back for more Emily Kidson Product recommendations by Amphora staff have been spot on. I have been using Amphora products for over a year now. Safety during pregnancy and lactation has not been established. Botanical Description Symphytum officinale is a 1-4 ft (30-120 cm) tall perennial herb with a branched fusiform root that is black on the outside and white on the inside. Wont go anywhere else now that I've found you. Other Common Names Knitbone, Boneset, Bruisewort, Slippery Root, Ass Ear, Black Root, Knitback, Healing Herb. All rights reserved.I've been buying Amphora Aromatics products for the last 2 yrs and I've found really great and great quality. Even with the worst-case calculation, the currently discussed guidelines on PA overestimate the risk related to topical preparations.Ĭomfrey Lycopsamine Pyrrolizidine alkaloids Symphytum × uplandicum Nyman Transcutaneous absorption.Ĭopyright © 2020 Elsevier Inc. The theoretical skin penetration of 4.9% of the applied quantity of lycopsamine largely resulted from the worst case approach of assuming the presence of at least a quantity corresponding to the limit of detection - the true penetration is probably considerably lower. In five of six diffusion cells, there was no detectable lycopsamine within the skin and only 0.6 ± 0.4% of the applied dose in the receptor fluid. Only small amounts of the applied quantity of lycopsamine had migrated through the skin sample into the receptor cell side of the diffusion cell after 24 h. PAs could be excluded in the non-spiked cream with a limit of detection of 8 μg/kg. In this study, lycopsamine served as a model substance for measuring the extent of skin permeation of PAs following the application of a spiked comfrey cream (Symphytum officinale s.l.) to abdominal skin from human donors in Franz diffusion cells. European Union guidelines indiscriminately discuss a permitted daily exposure (PDE) for pyrrolizidine alkaloids (PA) of up to 0.007 μg/kg body weight for oral and for topical exposure to herbal medicinal products.
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